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Thymalin

Also known as thymus polypeptide, thymic extract bioregulator, Thymulen

Thymalin is a polypeptide bioregulator extracted from calf thymus glands, distinct from Thymulin (FTS) which is a specific nonapeptide. Thymalin is a complex mixture of thymic peptides that comprehensively restores thymic function and immune regulation. It has the most extensive clinical research of all thymic bioregulators, with 30+ year studies in Russia showing dramatic improvements in longevity, immune function, and age-related disease risk.

Typical dosing
10–20 mg · Once daily
Administration
SubQ, IM
Half-life
Short; hours
Level
intermediate

How it works

Complex polypeptide mixture that restores thymic epithelial cell function and normalizes production of thymic hormones (thymulin, thymosin alpha-1, thymopoietin). Stimulates T-cell precursor differentiation, normalizes CD4/CD8 ratio, and reduces chronic low-grade inflammation (inflammaging).

Benefits

  • Most extensively studied thymic bioregulator — 30+ year Russian clinical data
  • Restores thymic hormone production and T-cell differentiation
  • Significantly improves immune function in elderly
  • Associated with reduced all-cause mortality in long-term studies
  • Improves vaccine response in immunosenescent patients
  • Reduces risk of age-related infections
  • Comprehensive immune anti-aging effects

Dosing

10–20 mg · Once daily

Typical course: 10mg/day SubQ or IM for 10 days. Repeat 1–2x yearly. Some longevity protocols use alongside Epithalon.

Ranges reflect commonly cited research protocols, not a prescription. Dose with a licensed provider.

Reconstitution

10mg vial with 1mL BAC water = 10mg/mL. Use within 30 days refrigerated.

Helix’s free reconstitution calculator gives you the exact draw volume → get the app

Common stacks

Reported side effects

  • Generally very well tolerated
  • Mild injection site irritation
  • Transient fatigue in first few days possible

Who it’s for

Adults 40+ seeking comprehensive immune anti-aging. Those with immunosenescence, chronic illness, or high infection susceptibility. One of the most evidence-backed longevity peptides in the Khavinson series.

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