Sermorelin
Also known as GHRH 1-29, Geref
Sermorelin is the first 29 amino acids of GHRH — the natural signal that tells your pituitary to release GH. It's one of the most widely prescribed GH-stimulating peptides through anti-aging clinics and is often considered the most legitimate entry point into GH peptide therapy.
How it works
Direct GHRH receptor agonist — identical mechanism to endogenous GHRH but shorter half-life. Stimulates pulsatile GH release preserving natural GH axis feedback.
Benefits
- Increases natural GH and IGF-1 production
- Improves body composition — less fat, more lean mass
- Better sleep quality, especially deep/slow wave sleep
- Increased energy and recovery
- Bone density improvements
- Anti-aging effects
Dosing
200–500 mcg · Once daily (before bed preferred)
Bedtime dosing maximizes GH pulse during sleep. Compound with Ipamorelin for synergy.
Ranges reflect commonly cited research protocols, not a prescription. Dose with a licensed provider.
Reconstitution
3mg vial with 3mL BAC water = 1mg/mL
Helix’s free reconstitution calculator gives you the exact draw volume → get the app
Common stacks
Reported side effects
- Flush or tingling at injection site
- Headache initially
- Water retention
- Rare: hypoglycemia
Who it’s for
Adults over 30 with declining GH levels, those interested in anti-aging therapy, or anyone new to GH peptides. Often available through TRT/anti-aging clinics.
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