NAD+
Also known as Nicotinamide Adenine Dinucleotide, IV NAD, NAD infusion, Injectable NAD+
NAD+ is a coenzyme essential for mitochondrial energy production, DNA repair via PARP enzymes, and sirtuin-mediated longevity pathways. Injectable and IV NAD+ bypasses gut conversion to deliver NAD+ directly to systemic circulation. Intracellular NAD+ levels decline ~50% between ages 40–60 — replenishing them is one of the most credible longevity interventions available.
How it works
Serves as a hydride acceptor in the TCA cycle and oxidative phosphorylation, and as substrate for PARP enzymes (DNA repair), sirtuins (metabolic and epigenetic regulation), and CD38 signaling. Restoring declining NAD+ levels reactivates mitochondrial function and stress-response pathways.
Benefits
- Increased mitochondrial energy production (ATP synthesis)
- Activates sirtuins — longevity-associated gene regulators
- Enhanced DNA damage repair via PARP-1
- Improved cognitive clarity and mental energy
- Reduced neuroinflammation
- Improved insulin sensitivity
- Accelerated cellular recovery and reduced fatigue
- Support for addiction recovery at high IV doses
Dosing
100–1000 mg · 1–5x per week (loading), then weekly to monthly
IV: 250–1000mg per session — slow infusion required. IM: 100–300mg per session. SubQ: 25–100mg. Beginner IV start: 250mg. Experienced: 500–1000mg.
Ranges reflect commonly cited research protocols, not a prescription. Dose with a licensed provider.
Reconstitution
Lyophilized powder. For IV: dilute into 100–250mL normal saline bag. For IM/SubQ: reconstitute to 100mg/mL with sterile water.
Helix’s free reconstitution calculator gives you the exact draw volume → get the app
Common stacks
Reported side effects
- Flushing and chest tightness during IV (rate-dependent — slow the drip)
- Nausea during infusion
- Abdominal cramping
- Headache
- Fatigue 24–48h after high-dose sessions
- IM/SubQ generally well tolerated
Who it’s for
Adults over 35 experiencing fatigue, brain fog, or metabolic decline. Biohackers targeting longevity. Those recovering from addiction. Anyone with mitochondrial dysfunction or high oxidative stress.
Track NAD+ in Helix
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