IGF-1 (Mecasermin)
Also known as Mecasermin, Increlex, Insulin-like Growth Factor-1, rhIGF-1
Recombinant human IGF-1, the prescription parent of analogs like IGF-1 LR3 and IGF-1 DES. FDA-approved (as Increlex) for severe primary IGF-1 deficiency. IGF-1 mediates most of growth hormone's downstream anabolic effects.
How it works
Activates the IGF-1 receptor, triggering PI3K/Akt and MAPK pathways that drive protein synthesis, cell proliferation, and survival. Also binds the insulin receptor weakly, which underlies its hypoglycemia risk.
Benefits
- Promotes muscle growth
- Supports tissue and nerve repair
- Improves glucose uptake
- Enhances recovery
- Carries the anabolic effects of growth hormone
Dosing
40–120 mcg · 1-2x daily with food
Clinical Increlex dosing is weight-based (mg/kg twice daily with a meal to avoid hypoglycemia). Performance use is off-label, far smaller, and should never be dosed fasted.
Ranges reflect commonly cited research protocols, not a prescription. Dose with a licensed provider.
Reconstitution
Increlex ships as a solution; research IGF-1 powder is reconstituted with bacteriostatic or acetic-acid water and refrigerated.
Helix’s free reconstitution calculator gives you the exact draw volume → get the app
Common stacks
Reported side effects
- Hypoglycemia (always take with food)
- Headaches
- Fluid retention
- Tonsillar hypertrophy
- Theoretical tissue overgrowth
Who it’s for
Advanced users, or those medically indicated for IGF-1 deficiency. High hypoglycemia risk demands caution and food timing.
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