Kisspeptin-10
Also known as Kp-10, Kisspeptin 234
Kisspeptin-10 is a naturally occurring neuropeptide that stimulates LH (luteinizing hormone) and FSH release from the pituitary — driving testosterone and estrogen production. It's the master regulator of reproductive axis, used for both fertility and libido optimization.
How it works
Binds Kiss1R (GPR54) receptors on GnRH neurons in the hypothalamus, triggering GnRH release and the downstream LH/FSH surge. Acts as the 'master switch' of the reproductive axis.
Benefits
- Stimulates LH and FSH release, boosting testosterone
- Enhances libido and sexual function via hormonal pathway
- Studied for male fertility and hypogonadism
- May restore HPG axis suppressed by testosterone replacement
- Social bonding and emotional enhancement effects
Dosing
50–100 mcg · On-demand or 3–5x per week
On-demand: inject 30 min before sexual activity. Protocol use: 50–100mcg 3–5x/week to maintain LH pulses.
Ranges reflect commonly cited research protocols, not a prescription. Dose with a licensed provider.
Reconstitution
Standard reconstitution
Helix’s free reconstitution calculator gives you the exact draw volume → get the app
Common stacks
Reported side effects
- Generally well tolerated
- Potential LH surge (desired effect)
- Mild injection site irritation
Who it’s for
Men on TRT wanting to maintain fertility or restart natural testosterone production. Those with low LH/FSH. Used with PT-141 for comprehensive sexual optimization.
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